Early-onset colorectal cancer detection through a non-invasive label-free electrochemical immunosensor probe
Presenter: Ruma Paul, MS Session: Cancer and Cancer Related Alterations, Detection Approaches, and Molecular Characterization Time: 4/22/2026 9:00:00 AM → 4/22/2026 12:00:00 PM
Authors
Ruma Paul 1 , Md Zahirul Islam Khan 2 , Soumya Nair 2 , Alicia I Loya 1 , Sourav Roy 2 , Carlos R. Cabrera 1 1 Chemistry and Biochemistry, The University of Texas at El Paso, El Paso, TX, 2 The University of Texas at El Paso, El Paso, TX
Abstract
Early-onset colorectal cancer (CRC; ct /R cti ). The resulting calibration curve (ΔR ct /R cti vs Ag) demonstrated strong linearity (R 2 = 0.95) from 10-100 ng/µL, with a detection limit of 0.71 ng/µL. To further enhance stability and antifouling performance in complex biofluids, we are integrating a porous BSA-glutaraldehyde-gold nanowire (BSA-GA-AuNW) hydrogel onto Au interdigitated microelectrodes, followed by antibody immobilization and testing of early-onset CRC biomarkers. This conductive, hydrophilic matrix is expected to improve sensitivity and specificity while enabling reliable blood-based measurements. This non-invasive, low-cost electrochemical probe has strong potential to expand screening and improve early detection of CRC, especially among younger and underserved populations, thereby improving the survival rates.
Disclosure
R. Paul, None.. A. Loya, None.. C. Cabrera, None.
Cited in
Control: 3233 · Presentation Id: 6791 · Meeting 21436