R7 FIH startup lag section added to report revealing community CRO speed advantage over academic centers
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obs· Harvested: 2026-05-02 · Original date: 2026-05-02T02:59:25.254Z Metadata:{"project":"lunhsiangyuan","type":"feature","obs_id":64906}
obs/64906 · feature · 2026-05-02T02:59:25.254Z
R7 FIH startup lag section added to report revealing community CRO speed advantage over academic centers
Round 7 completed and integrated into the FIH intelligence report. The section analyzes site startup efficiency by cross-referencing FIH trial counts with v_site_q1_startup_lag metrics measuring days between trial registration and first patient enrollment. Results expose a critical paradox: high-experience academic centers operate slowest. Memorial Sloan Kettering (19 ADC FIH trials) averages 618 days while City of Hope (9 bispecific FIH trials) requires 686 days. In contrast, community Phase 1 CROs demonstrate exceptional speed: START San Antonio launches ADC trials in 21 days, NEXT Virginia in 87 days—5-8x faster than academic counterparts. MD Anderson emerges as an outlier combining both volume (27 ADC FIH trials) and speed (187 days), positioning it uniquely for BD partnerships. The analysis also reveals AACT database limitations: European and Asian sites (VHIO, NCC Tokyo, Dana-Farber) show N/A lag data despite high FIH trial counts, indicating incomplete state transition tracking for non-US sites. Korean centers (Asan, Samsung, Seoul National) show moderate but consistent 327-391 day performance, outperforming US academic centers but trailing community CROs. Report now contains 7 completed rounds (R1-R7) with 8 rounds remaining.
Concepts: [“what-changed”,“pattern”,“trade-off”]
Facts: [“R7 section appended to output/adc-bispecific-landscape.md at lines 351-406 (56 new lines)”,“Three data tables added: ADC FIH top sites with lag, bispecific FIH top sites with lag, global fastest sites”,“START San Antonio identified as fastest ADC FIH site at 21 days average lag”,“Memorial Sloan Kettering and City of Hope identified as slowest major sites at 618 and 686 days respectively”,“MD Anderson highlighted as unique balance: 27 ADC FIH trials with 187-day lag (high volume + above-average speed)”,“Community Phase 1 CROs (START, NEXT) shown to be 5-8x faster than academic centers (MSK, City of Hope)”,“Spanish and Japanese top sites (VHIO, NCC Tokyo) show N/A lag data due to AACT coverage gaps for non-US sites”,“Five strategic judgments documented: experience-speed paradox, CRO speed advantage, MD Anderson exception, AACT coverage gaps, Korean stability”,“Temporary Python scripts removed after successful execution (r7_lag.py, r7_lag2.py)”]
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