R8 FIH site stability analysis completed revealing Korean centers achieve 92-98% stability rates
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obs· Harvested: 2026-05-02 · Original date: 2026-05-02T03:12:21.196Z Metadata:{"project":"lunhsiangyuan","type":"feature","obs_id":64912}
obs/64912 · feature · 2026-05-02T03:12:21.196Z
R8 FIH site stability analysis completed revealing Korean centers achieve 92-98% stability rates
Round 8 site stability analysis successfully completed after abandoning background task execution in favor of direct Python script invocation. The r8_v2.py script retrieved FIH trial counts, stability metrics from v_site_q4_stability view, and startup lag from v_site_q1_startup_lag view, then performed in-memory joins using lowercase name matching. Results expose critical quality differentials among high-volume FIH sites. Korean medical centers demonstrate exceptional enrollment consistency: Samsung Medical Center leads at 98.5% stability across 67 resolved trials, Seoul National University at 93.9% (77 resolved), and Asan Medical Center at 92.1% (70 resolved). This consistency persists despite moderate startup speeds (265-391 days). The “Research Site” entry achieves perfect 100% stability but with low sample size (7 resolved trials). MD Anderson emerges as the optimal BD partner combining volume leadership (36 total FIH), operational speed (187-day lag), and reliable stability (81.0% across 128 resolved trials). City of Hope’s 75.9% stability raises concerns despite its #3 ranking in bispecific FIH count. The elite site analysis identifies 10 sites meeting triple criteria (volume + speed + reliability), with Korean centers occupying 3 of top 4 positions. European and Asian sites show data gaps due to AACT’s incomplete trial status tracking outside the US, explaining missing metrics for VHIO and NCC Tokyo despite high FIH counts from R6.
Concepts: [“what-changed”,“pattern”,“trade-off”]
Facts: [“R8 analysis executed successfully via direct Python script r8_v2.py avoiding background task failures”,“Samsung Medical Center shows highest stability among major sites at 98.5% (67 resolved trials)”,“Research Site achieves perfect 100% stability with 138-day lag and 12 total FIH trials”,“MD Anderson combines high volume (36 FIH), fast startup (187 days), and good stability (81.0%, 128 resolved)”,“City of Hope shows concerning 75.9% stability rate despite 60 resolved trials and 9 bispecific FIH count”,“Korean Big 3 all exceed 90% stability: Samsung 98.5%, Seoul National 93.9%, Asan 92.1%”,“Spanish and Japanese top sites (VHIO, NCC Tokyo, Navarra, Germans Trias) missing stability data due to insufficient resolved trials (n_resolved < 5 filter)”,“Elite site filter identifies 10 sites meeting FIH≥5 + Stab≥80% + Lag<400 criteria”,“Florida Cancer Specialists shows 94.1% stability but ADC-only (0 bispecific FIH)”,“Peter MacCallum and Royal Marsden achieve 87-92% stability with balanced dual-modality portfolios”]
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