FIH Scout database contains 40+ HNSCC first-in-human trials with detailed metadata
Source type:
obs· Harvested: 2026-05-03 · Original date: 2026-05-03T12:19:45.280Z Metadata:{"project":"lunhsiangyuan","type":"discovery","obs_id":65001}
obs/65001 · discovery · 2026-05-03T12:19:45.280Z
FIH Scout database contains 40+ HNSCC first-in-human trials with detailed metadata
The primary session queried the FIH Scout SQLite database at ~/Projects/oncology-fih-research/data/fih-scout.db to extract HNSCC first-in-human trial data for the CEO briefing appendix. First confirmed database schema showing trial table with 20 columns including nct_id, brief_title, phases, overall_status, start_date, and is_fih_subset flag. Then executed query joining trial, v_trial_indication_family, trial_intervention, and sponsor tables filtered by family_key=‘head_neck_cancer’ and is_fih_subset=1, extracting 40 trials sorted by start_date DESC. Results include recent 2026 trials: EPI-326 (EpiBiologics) for EGFR-mutant NSCLC/HNSCC, [177Lu]Lu-AKIR001 radiopharmaceutical (Karolinska), SIM0610 (Simcere), and QLS5316 (Qilu). Data provides NCT IDs, intervention names, sponsors, start dates, phases, and recruitment status for the “Appendix — Molecule Fact Sheets” section of the planned briefing document, complementing the AACR 2026 abstracts and Desktop Wiki molecule analyses.
Concepts: [“how-it-works”,“what-changed”]
Facts: [“FIH Scout database schema confirmed with trial table containing nct_id, brief_title, phases, overall_status, start_date, sponsor_id, is_fih_subset, location_count, and enrollment_count columns”,“Database query extracted 40 HNSCC FIH trials using v_trial_indication_family join on family_key=‘head_neck_cancer’ with is_fih_subset=1 filter”,“Most recent trials include NCT07462377 (EPI-326, EpiBiologics, 2026-04), NCT06639191 ([177Lu]Lu-AKIR001, Karolinska, 2026-01-28), NCT07348211 (SIM0610, Simcere, 2026-01-19)”,“Trial data includes NCT IDs, intervention names, sponsors, start dates, phases, and recruitment status for populating molecule fact sheet appendix in HNSCC CEO briefing”]
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