Recent Work Focus on Bispecific/ADC Coverage Gap and PSCC Audit Iterations
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obs· Harvested: 2026-05-03 · Original date: 2026-05-03T13:36:26.494Z Metadata:{"project":"lunhsiangyuan","type":"discovery","obs_id":65066}
obs/65066 · discovery · 2026-05-03T13:36:26.494Z
Recent Work Focus on Bispecific/ADC Coverage Gap and PSCC Audit Iterations
Git history reveals intensive iterative work across two tracks: (1) systematic claim validation through 22 PSCC rounds that surfaced data quality issues like site name fragmentation and sampling biases, and (2) expanding coverage beyond Phase 1 FIH-only scope by building a supplement ETL for ADC and bispecific antibodies across all phases. The PSCC audit approach appears to be a formal methodology for challenging quantitative claims in pitch materials, with documented AGREE/DISAGREE verdicts. The supplement pipeline addresses the Phase 3 gap identified in memory (6+ bispecific trials from 2025-2026 were missing). Recent MCP tool additions provide multi-axis site/PI search capabilities built on top of the completed v10 site-depth views. Work appears to be transitioning from infrastructure completion toward BD/investor communication with trilingual pitch deck generation.
Concepts: [“how-it-works”,“pattern”,“problem-solution”]
Facts: [“Recent commit history includes 22 PSCC (Pseudo-Systematic Claim Challenge) audit rounds with detailed verdict documentation”,“New etl/supplement_adc_bispecific.py pipeline implements multi-query fetch with deduplication and incremental loading”,“Output directory contains adc-bispecific-landscape.md report plus cancer-specific funnel reports (Lung, Breast, Bladder, HCC, Colorectal)”,“PSCC rounds caught specific issues: site fragmentation, subsetting bias, sponsor-mix confounding, ecological fallacy”,“Coverage audit tooling added via scenario depth audit scripts and coverage-runs subdirectory”,“Four new MCP v10 tools deployed: site search/shortlist/profile plus PI RSS (rising star score)”]
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